ASSCR 2023 - Spotlight on Cell Therapies

BioStatus products DRAQ5™ & DRAQ7™ are, of course, used in countless research articles in pursuit of novel cell therapies.  They are trusted by pharma, biotechs and leading research institutes globally.

All BioStatus products are manufactured to the highest standards, from synthesis to packaging, under ISO 9001:2015 certificated processes.

But why should YOU choose them for development, characterisation and quality assurance of cell therapies?

        Where to buy: Sapphire Bioscience - please visit their booth!

To help you, here are some key examples where they have been components of flow cytometric analysis and cell sorting relevant to cell therapies, with hyperlinks to detailed documents and citations:

• Phenotypic analysis: easily gate singlet nucleated cells from doublets and debris, &..
• Cell Cycle / DNA Content Analysis: no-lyse, no wash direct method with minimal sample prep

• Side population analysis: exclude dead cells from disturbing the data

• Monocyte purity check: in preparation of therapeutic macrophages 

• Determining very rare antigen-specific T-cells

• ISHAGE CD34+ Stem Cell Enumeration: more reliable gating 
• cell therapy QC review article
• poster from European ref. lab.

• DNA Double-Strand Break Detection: assessing DSB repair capacity post-cryopreservation (IFC) 

• Micronucleus Detection: high-throughput genotoxicity testing (IFC)

• Smarter Cell Health and Apoptosis Assays: allowing multi-parameter and temporal options

• Single Cell Analysis: industry-standard gating of cells or nuclei for transcriptomics & genomics

• Cell-killing capacity: temporal monitoring of cytotoxic function

• Phagocytosis function: track fluorescence from prey to predator cells

DRAQ7™ to the rescue..

Did you know? You can add DRAQ7™ to a pre-existing chromophore panel when it is later realised a viability dye is needed!  Or, you can use the same concept to create a virtual channel that simplifies any compensation challenges for the other components or even to simply extend the capacity of your cytometer!

See how here

Fluorescence microscopy and high-content imaging

DRAQ5™ has been cited in many thousands of articles as the nuclear counterstain for fixed and live end-point fluorescence microscopy and in high-content imaging screens for drug discovery. 

DRAQ7™ enables time-lapse monitoring of cell health, for many days without inherent toxicity yet faithfully reporting cell death events.

ASK US! If you have any questions or need to discuss a specific assay we are only too happy to help out. Send an email to: enquiry@biostatus.com

        Where to buy: Sapphire Bioscience - please visit their booth!

IFC = Imaging Flow Cytometry

#ASSCR2023