A team at NTNU, Trondheim in Norway have shown that IONPs apparently
inhibit LPS induced pro-inflammatory cytokine production.
In one experimental procedure they used confocal microscopy
(combining fluorescence and transmission) to detect impact on the
internalisation of LPS by nanoparticles, using DRAQ5 as the nuclear
counterstain in monocytes.
One premise
of this work is that co-stimulation of the normal human immune system is a common
occurrence and therefore such observations should be of concern.
Reference:
Grosse, S.,
Stenvik, J., & Nilsen, A. M. (2016).
Iron oxide nanoparticles modulate
lipopolysaccharide-induced inflammatory responses in primary human monocytes.
International
Journal of Nanomedicine, 11, 4625.
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