Human Embryonic Stem Cells - an ultrastructural analysis of nuclei

Scientists from U Mass Med School have undertaken a detailed study of the nuclei of human embryonic stem cells (hES) to better understand the possible implications of the different features and how these might impact on the likely pluripotence of these cells.

The far-red DNA binding probe DRAQ5 was deployed by the authors to observe the expression and presence of nuclear pores consistent with the appropriate phenotype, but not a residue of the source cells after many cell divisions.

To quote the authors: "The architectural organization of human ES cell nuclei has important implications for cell structure – gene expression relationships and for the maintenance of pluripotency."

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